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discovery accelerator  (Astellas)

 
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    Astellas discovery accelerator
    Discovery Accelerator, supplied by Astellas, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/discovery+accelerator/advanced+accelerator+applications/pm38678148-38-0-2
    Average 90 stars, based on 1 article reviews
    discovery accelerator - by Bioz Stars, 2026-09
    90/100 stars

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    other:

    Article Title: Linear ubiquitination-induced necrotic tumor remodeling elicits immune evasion.
    Article Snippet: 1 Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto University, Japan 2 Alliance Laboratory for Advanced Medical Research, Graduate School of Medicine, Kyoto University, Japan 3 Discovery Accelerator, Astellas Pharma Inc, Ibaraki, Japan 4 Breast Cancer Unit, Graduate School of Medicine, Kyoto University Hospital, Japan

    Article Title: Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors.
    Article Snippet: Although KRAS protein had been classified as an undruggable target, inhibitors of KRAS G12C mutant protein were recently reported to show clinical efficacy in solid tumors.. In our previous report, we identified 1-{2,7diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivative (1) as a KRAS G12C inhibitor that covalently binds to Cys12 of KRAS G12C protein.. Compound 1 exhibited potent cellular pERK inhibition and cell growth inhibition against a KRAS G12C mutation-positive cell line and showed an antitumor effect on subcutaneous administration in an NCI-H1373 (KRAS G12C mutation-positive cell line) xenograft mouse model in a dose-dependent manner.

    Article Title: Sphingosine-1-phosphate receptor 1/5 selective agonist alleviates ocular vascular pathologies.
    Article Snippet: 2Discovery Accelerator, Astellas Pharma Inc., Tsukuba, Japan.

    Article Title: Activation of ILC2s through constitutive IFNγ signaling reduction leads to spontaneous pulmonary fibrosis.
    Article Snippet: 12Discovery Accelerator, Astellas Pharma Inc., Ibaraki, Japan.



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    Image Search Results


    OSP Extension Module concept. PK‐Sim models are composed of individual Building Blocks ( https://docs.open‐systems‐pharmacology.org/v12/open‐systems‐pharmacology‐suite/modules‐philsophy‐building‐blocks ) separating information used for model building into dedicated groups. Building Blocks are combined to generate a model, they can be reused and combined to create different models. When transferring a PK‐SIM simulation to MoBi, model Building Blocks are further organized into a module. Modules represent either a full‐scale PBPK model imported from PK‐Sim (blue rectangle), or extension modules (orange rectangles) that represent model modifications or adaptations such as disease populations, custom administration routes, altered or new special structures that represent tissues or any other modification of the underlaying Building Blocks. Extension Modules provide a standardized, systematic, and reproducible way to efficiently develop and share complex models or model modifications across different projects and modeling scientists.

    Journal: CPT: Pharmacometrics & Systems Pharmacology

    Article Title: Open Systems Pharmacology Community Conference ( OSP ‐ CC ) Proceedings 2025

    doi: 10.1002/psp4.70217

    Figure Lengend Snippet: OSP Extension Module concept. PK‐Sim models are composed of individual Building Blocks ( https://docs.open‐systems‐pharmacology.org/v12/open‐systems‐pharmacology‐suite/modules‐philsophy‐building‐blocks ) separating information used for model building into dedicated groups. Building Blocks are combined to generate a model, they can be reused and combined to create different models. When transferring a PK‐SIM simulation to MoBi, model Building Blocks are further organized into a module. Modules represent either a full‐scale PBPK model imported from PK‐Sim (blue rectangle), or extension modules (orange rectangles) that represent model modifications or adaptations such as disease populations, custom administration routes, altered or new special structures that represent tissues or any other modification of the underlaying Building Blocks. Extension Modules provide a standardized, systematic, and reproducible way to efficiently develop and share complex models or model modifications across different projects and modeling scientists.

    Article Snippet: Systematic development of PBPK models to support candidate selection and accelerate drug discovery , Grégori Gerebtzoff (Novartis).

    Techniques: Transferring, Modification